There are three known ways that a proto-oncogene can be converted into an oncoge

Question

There are three known ways that a proto-oncogene can be converted into an oncogene. One involves a deletion or point mutation that leads to a(n) [___] regulatory protein that is otherwise synthesized in normal amounts. A second involves [___] of a normal gene sequence, leading to [___] of a normal regulatory protein. Thirdly, a(n) [___] brings a normal gene under the influence of a genetic regularty element that drives [___] expression of that gene.

Please select one:

(1) inactive, mutation, enhanced production, oncogene, excessive

(2) hyperactive, amplification, overproduction, chromosome rearrangement, elevated

(3) defective, loss, absense, oncogene, reduced

(4) hypoactive, amplification, excessive production, translocation, hyperactive

(5) hyperactive, deletion, loss, translocation or inversion, depressed

Explanation / Answer

(2) hyperactive, amplification, overproduction, chromosome rearrangement, elevated

There are three known ways that a proto-oncogene can be converted into an oncogene. One involves a deletion or point mutation that leads to a(n) [_hyperactive__] regulatory protein that is otherwise synthesized in normal amounts. A second involves [_amplification__] of a normal gene sequence, leading to [_over production__] of a normal regulatory protein. Thirdly, a(n) [_chromosome rearrangement__] brings a normal gene under the influence of a genetic regulatory element that drives [_elevated__] expression of that gene.

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