In the absense of antigen stimulation, a human can probably make more than 10^12

Question

In the absense of antigen stimulation, a human can probably make more than 10^12 different antibody molecules in what is called its primary antibody repertoire. After stimulation by antigen binding and [____], B cells can switch from making IgM and IgD to making other classes of antibodies, a process called [____] and which requires gene rearrangements in the [____] gene group. In addition, the affinity of these antibodies for their antigen progressively increases over time, a process called [____]. Thus, antigen stimulation generates a [____] with a greatly increased diversity of got Ig classes and antigen-binding sites.

Please choose one of the following:

(1) helper T cells, class switching, heavy chain, affinity maturation, secondary antibody repertoire

(2) cytotoxic T cells, domain switching, antibody, affinity maturation, Ig library

(3) helper T cells, class switching, IgG, kinetic stability, secondary antibody response

(4) macrophages, hypervariable region maturation, IgG/IgM, affinity maturation, V(D)J recombination

(5) dendritic cells, class switching, heavy chain, affinity maturation, V(D)J-C recombination

Explanation / Answer

Ans. (1) helper T cells, class switching, heavy chain, affinity maturation, secondary antibody repertoire

Related Questions

Navigate

• Browse (All)
• Browse I
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.