Choose two genes associated with your chosen cancer below (ovarian). Answer the

Question

Choose two genes associated with your chosen cancer below (ovarian). Answer the following questions for each gene. ANSWERRRRRRRR the questions

Analysis of Associated Cancer Ger es Choose three genes associated with your chosen cancer below. Answer the following questions for each gene » What is the function of the gene? Is this a tumor suppressor or proto-oncogene? Why? » Which hallmarks are associated with the gene? If there are no hallmarks explain how the gene relates to cancer Find a molecular diagram related to the role of this gene in cancer. Create a linear molecular diagram of the illustrated pathway. You may use your text book or find an image on the web. You must send me a picture of the molecular diagram you are working with so I can grade your linear molecular diagram. » Where would you intervene for a targeted therapeutic approach? Would you activate or inhibit this target? 2. Ovarian Cancer » CDHI » PTEN o TP53 o RAD50 o RB1

Explanation / Answer

1). Genes associated with ovarian cancer include BRCA1 and BRC2 (germ line mutations in these genes causes ovarian cancer). Particularly mutations in BRCA1 contributes to increased risk of developing ovarian cancer (the risk increase by 10 to 45%).

2). The BRCA genes are tumour suppressor genes, they are necessary for the repair process that occur during cell division. Mutations in these genes confer abnormal cell division.

3). Hallmarks associated familial ovarian cancer induced by mutations in BRCA gene include early onset of the disease and or occurrence of other cancers such as breast cancer, endometrial cancer, etc.

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