When a folded protein in solution is heated to a high enough temperature, its po

Question

When a folded protein in solution is heated to a high enough temperature, its polypeptide chain will unfold to become the "denatured protein"- a process known as denaturation. The temperature at which most of the protein unfolds is called the "melting" temperature. The melting temperature of a certain protein is found to be 63 oC, and the enthalpy of denaturation is 510 kJ/mol.

a) Estimate the entropy of denaturation, assuming that the denaturation is a single step equilibrium process; that is,

folded protein <======> denatured protein. Is this a chemical or physical process - Similar to ice melting or to bonds broken?

The single polypeptide protein chain has 98 amino acids. Calculate the entropy per amino acid. Do you think that the denaturing process is increasing the entropy of the protein or decreasing the entropy and why? What about the entropy of the universe ?Suniv?

b) Assuming that ?H and ?S do not change with temperature, determine ?G for the denaturation at 20oC. Is this a reasonable assumption and why.

c) Assuming that the ?G value from part b) is ?Go, for the denaturation, determine the value of the equilibrium constant for the process at 20oC. If you know ?H and ?S, what formula would be best to use?

2. Large quantities of hydrogen are needed for the Haber synthesis of ammonia. One preparation of hydrogen involves the reaction of carbon monoxide with steam at 300oC in the presence of a copper-zinc catalyst:

                        CO(g) + H2O(g)  

Explanation / Answer

Refer here:

http://www.orgsyn.org/

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