Which of the following defines a Robertsonian translocation: a) Part of one chro

Question

Which of the following defines a Robertsonian translocation: a) Part of one chromosome is swapped with a segment of an entirely different chromosome-no net loss or gain b) the "p" arms of two acrocentric chromosomes are lost and the remaining "q" arms are fused together c) the "q" arms of two acrocentric chromosomes are lost and the remaining "p" arms are fused together d) The "p" arms of two acrocentric chromosomes make a reciprocal exchange; chromosome number remains the same Which of the following types of chromosome alterations is subject to the POSITION EFFECT? a) inversions, translocations b) duplications, deletions c) polyploidies d) trisomies, monosomies. All of the following statements about individuals who are inversion heterozygotes are true, EXCEPT ONE. Which one is it? a) inversions "appear" to suppress crossing over, but only because the cross over products are nonviable b) individuals can have problems producing offspring c) all individuals with inversions will have some type of clinical problem because the genes are expressed in the wrong order d) if recombination occurs within the inverted segment, it can result in gametes with duplications, deletions, acentric, and/or dicentric chromosomes Currently, there are two different invasive methods of prenatal diagnosis: amniocentesis and chorionic villus sampling (CVS). Which of the following statements is TRUE: a) Both procedures are typically done at about 10 weeks gestation b) CVS involves collecting cells from the fluid surrounding the baby, while amniocentesis requires extracting a solid sample of tissue from what will eventually form the placenta c) Both methods involve growing cells and allow karyotype analysis and DNA analysis on the sample d) They both require taking a blood sample from the mother

Explanation / Answer

answers:

1) c

Explanation: Fusion of 2 acrocentric very close to the centrosomes, most often in p arms gives dicentric chromosome.

2) a

Explanation: Position effect is the effect on the expression of a gene when its location in chromosome is changed by translocation

3) a

4) b

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