The laminin heterotrimer normally bridges the __________ protein on the ________

Question

The laminin heterotrimer normally bridges the __________ protein on the __________ and the __________ protein in the __________ Mutant LAMC2 causes blisters separating the __________ and the __________ (list in order from the outside to the inside). What are two functions of the microtubule motor proteins dynein and kinesin? (i).__________ (ii) __________ (iii) Which function is blocked by the use of colchicine in gout? Mitesiso You are trying to find the cholesterol-deficiency mutation in Holstein calves on the chromosome to the left and find a significant association of disease with SNP a, which is a G nucleotide, whereas SNP A is an A nucleotide. (i) The statistical test for significance tests the hypothesis that two things are associated by random chance. To be significant, the p value must be less than or equal to 0.05. The p value for the association of SNP a with the disease is 1 times 10^-9. Is the probability that SNP a and the disease are associated by random chance high or low? __________ (ii) The p value for the association of SNP e with the disease is 1 times 10^-1. ls the probability that SNP e and the disease are associated by random chance high or low? ________ (ii) Is it more likely that SNP c or that SNP b is also associated with the disease? __________ Why? Use the terms crossing over or recombination. (i) A G protein is on when it is bound to __________ (ii) A G protein turns itself through _________ of __________ to __________ (iii) AG protein is activated by a ligand-bound acting as a GEF, which induces the G protein to release bound __________ and instead bind to ________ (iv) An oncogenic mutation in a G protein stops its __________ enzymatic activity. (i) A receptor tyrosine kinase (RTK) has a tyrosine kinase in its __________ that is induced to __________ itself on tyroshine when its __________ is bound by _________. This makes the tyrosine ____________, which allows amino acids that are _________ to bind to the tyrosine. Cutaneous mast cell tumors are one of the common neoplasms in dogs(7-21% of all cutaneous neoplasms) and are often aggressive resulting in death. Most of the mutations are in-frame duplications

Explanation / Answer

[I am answering paet 4 of your question. I hope it helps. Thanks ]

4.i. GTP

ii. dephosphorylation of GTP to GDP

iii. phosphate and GDP

iv. GTPase

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