In translational elongation, the growing peptide chain is transferred from the _

Question

In translational elongation, the growing peptide chain is transferred from the _____ the ribosome to the ______ site as a new peptide bond is formed. a) A; P b) P; A c) A; E d) E; P 5'-ATCAGATGTCCCATTTAGTCTGACCA -3' The sequence above agene. When the mRNA from this gene is translation what will be the first three amino acids? a) Met-Ser-Asp b) Ser-Asp-Glu c) Ile-Arg-Lys d) Met-Ser-His Misfolding of proteins is a serious problem in cells. Which of the following disease associated with an accumulation of misfolded proteins? a) Alzheimer's only b) Parkinson's only c) diabetes mellitus only d) Alzheimer's and Parkinson's which gel to the right corresponds to the situation where there is a nonsense mutation in the gene in the Mut Cell? a) Gel A b) Gel B c) Gel C d) Gel D which of the following is NOT a stage in cell signaling? a) Reception b) Transduction c) Response d) Termination What is the final result of mitosis in humans? a) genetically identical 2n somatic cells b) genetically different 2n somatic cells c) genetically identical 1n somatic cells d) genetically identical 2n gamete cells

Explanation / Answer

in translational elongation the growing peptide chain is transferred from the P side of the ribosome to A site as a new peptide bond is formed.

P site is known as peptidyl site , at the begining of elongation cycle it is filled with N-formylmethionyl t RNA or peptidyl-tRNA. mRNA is bound to the ribosome in such a way that the proper codon interaction with the Psite tRNA.

aminoaceyl-tRNA binding to the A sitestarts the transpeptidation reaction. it is catalysed by 23s rRNA( RIBOZYME ACTIVITY). the alpha amino group of the A site amino acid nucleophilically attacks the alpha carboxyl group of C terminal amino acid on the P site of tRNA.THE PEPTIDE Chain attached to the tRNA in P site is transferred to A siteas a peptide bond is formed between the chain and incoming amino acid.

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