Naproxen belongs to a class of pahrmaceuticals, the (S)-(+)-enantiomer is the de

Question

Naproxen belongs to a class of pahrmaceuticals, the (S)-(+)-enantiomer is the desired pharmacological activity while the (R)-(-) -enantiomer is potentially a liver toxin. Due to this, commercial Naproxen is sold as the S-(+)-enantimoer with high levels of optical purity.

Calculate the observed rotation (a) for naproxen from the following information:

%S= 95%                                           (a) literature= +66.0

Concentration = 35g/78mL                     path length=2dm

Explanation / Answer

specific rotation = optical rotation/(concentration*path length)

[? ] = ? / c*l

Given,

Observed rotation ? = +66.0

Concentration = 35g/78ml, then for 1ml Concentration is 0.448g/ml

path length = 2dm

Then, specific rotation is

[? ] = 66/(0.4487*2)

[? ] = +73.54degrees

Related Questions

Navigate

• Browse (All)
• Browse N
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.