A type III hypersensitivity reaction a. is stimulated by soluble antigen, mediat

Question

A type III hypersensitivity reaction
a. is stimulated by soluble antigen, mediated by IgG and results in excessive immune complex formation
b. is stimulated by soluble antigen, mediated by TH1 cells and results in macrophage activation
c. is stimulated by soluble antigen, mediated by IgE and results in mast cell degranulation
d. is stimulated by cell associated antigen, mediated by IgG and results in Complement activation
e. is stimulated by a cell associated antigen, mediated by cytotoxic T lymphocytes and results in the destruction of cells expressing the antigen

Explanation / Answer

The answer is d. Same classes of antibody as a type 2, which are 1gG and 1gM. In this case, antigen-antibody formation is affected and these complexes are deposited throughout the body, which can eventually lead to tissue damaging substances being released, fever, and complement activation.

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