You cloned and are expanding in vitro a human cytotoxic T cell, whose T-cell rec

Question

You cloned and are expanding in vitro a human cytotoxic T cell, whose T-cell receptor is specific for a tumor antigen. Consequently, your analyses of nucleic acids in this T-cell clone are very likely to detect the presence of [complete the sentence and assess the resulting statements (13-25) as either factually correct (= true) or incorrect (= false)]:

13. CD4 mRNA.

14. CD8 mRNA.

15. TCR chain mRNA.

16. AIRE mRNA.

17. IL-2R chain mRNA.

18. FoxP3 mRNA.

19. MHC class I chain mRNA.

20. MHC class II chain mRNA.

21. 2-microglobulin mRNA.

22. IgG heavy chain DNA.

23. TCR chain DNA.

24. TCR chain DNA.

25. FoxP3 DNA.

Explanation / Answer

Cytotoxic T cell is an activated state of T cell when it encounters a tumor antigen on an antigen presenting cell. It will have the following mRNA in the T cell clone

1. CD8 mRNA.

2. TCR chain mRNA.

3.  MHC class I chain mRNA.

4. 2-microglobulin mRNA.

5. TCR chain DNA.

6. TCR chain DNA.

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