In your new job with a biotech company, you created a new transgenic mouse strai

Question

In your new job with a biotech company, you created a new transgenic mouse strain that you nicknamed “I want a salary increase” (IWASI). IWASI mice constitutively express a transgene encoding a rearranged immunoglobulin heavy chain, whose transcription and translation lead to production of functional B-cell receptors (BCRs) with high affinities for a ubiquitous, murine, cell-surface antigen. In comparison with normal mice, your IWASI mice will very likely display [complete the sentence and assess the resulting statements (7-12) as either factually correct (= true) or incorrect (= false)]:

7. increased numbers of circulating B cells, because they have a growth advantage as a result of not having to rearrange their own immunoglobulin heavy chains.

8. increased apoptosis of bone marrow B cells, because of their autoreactive heavy chain expression.

9. decreased incidence of somatic hypermutation in order to reduce negative effects of autoreactivity of transgenic BCRs.

10. reduced numbers of naïve B cells exiting the bone marrow due to high levels of B-cell death during selection processes.

11. increased B-cell class switching, as a means of replacing the autoreactive heavy chain.

12. increased numbers of positively selected T cells in the thymus as a result of increased T-cell help required for B cells replacing the autoreactive heavy chain.

Explanation / Answer

7. true

8.false

9.true

10.true

11. true

12. false

The production of rearragenged b cells will prpduce more as there will be no constrain to effect it. During this process there are chances that the production of autoreactive heavy chain also increases.

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