Re- write this paragraph in your own words? Furthermore, the role of miR-22 and

Question

Re- write this paragraph in your own words?

Furthermore, the role of miR-22 and possible molecular mechanisms in EOC were investigated by several in vitro approaches and in a nude mouse model. Results from qRT-PCR showed that miR-22 was significantly downregulated in RCC samples compared with corresponding non-cancerous tissues, which was significantly associated with tumor stage and lymph node metastasis. Functional study demonstrated that enforced overexpression of miR-22 in renal cancer cells inhibited proliferation, migration and invasion, and induced cell apoptosis in vitro, and suppressed tumor growth in vivo. In addition, SIRT1 was identified as a direct target of miR-22 by a luciferase reporter assay. Overexpression of miR-22 activated p53 and its downstream target p21 and PUMA, and the apoptosis markers cleaved CASP3 and PARP, and inhibited epithelial-mesenchymal transition (EMT). These findings showed that miR-22 functioned as tumor suppressor in RCC and blocked RCC growth and metastasis by directly targeting SIRT1 in RCC, indicating a potential novel therapeutic role in RCC treatment.

Explanation / Answer

Besides the part of mir-22 and concievable atomic instruments in EOC were researched by a few in vitro approaches and a bore mouse demonstrate.Coming to qRT-PCR demonstrates that mir-22 was essential down regulated in RCC tests contrasted and relating non dangerous tissues,which was fundamentally connected with tumor stage and lymph hub metastasis..Useful review showed that implemented over expression of mir-22 in renal disease cells restrained multiplication,movement and attack and actuated cell apoptosis in vitro and smoothered tumor development in vivo.What's more,ISRT 1 was recogonized as an immediate focus on mir-22 by a luciferase columnist test. Over expression of mir-22 actuated P 53 and its down stream target p21 and jaguar and the apoptosis market cut CASP and PRAP and hindered epithelial-mesenchymal move (EMT).

These discoveries demonstrated that mir-22 worked as a tumor silencer in RCC and blocked RCC development and metastasis by straight forwardly focussing on SIRT1 in RCC showing a potential novel remedial part in RCC treatment.

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