Which of the following serve the entry pathway into lymph nodes for dendritic ce

Question

Which of the following serve the entry pathway into lymph nodes for dendritic cells to enter the lymph nodes? a. efferent lymphatic vessels b. Primary follicles c. afferent lymphatic vessels d. Medullary sinus e. HEV As mature dendritic cells drain into secondary lymphoid tissues, they interact with which cells to either provide a survival signal or activation signal? a. Naive B cells b. Naive CD 8 T cells c. Naive CD 4 T cells d. All of the above answer choices are correct e. Only answers choices b and c are correct Lymph drains from the thoracic duct into which of the following blood vessels? a. Hepatic Portal vein b. Subclavian vein c. Common Iliac arteries d. Pulmonary vein e. Hepatic artery After immature dendritic cells conduct phagocytosis in tissues, they differentiate and normally present pathogen peptide antigens obtained by phagocytosis on which of their surface molecules? a. CCR5 b. MHC class I c. MHC class II d. either MHC class I or MHC class II e. B7 (CD80/86) molecules The first step of a primary adaptive immune response against most foreign antigens is which of the following? a. Macrophage activation b. Opsonizing microorganisms c. Activation of specific T cells d. Activation of specific B cells e. Neutrophil activation Which of the following can recognize and bind to pathogen peptide antigens presented on self MHC of mature dendritic cells? a. B cell receptor that specifically binds to the antigen b. The specific binding T cell receptor c. The specific binding B cell antigen receptor and co-receptor d. The co-receptors CD 4 or CD 8 e. CD 28 After immature dendritic cells conduct phagocytosis of viruses in tissues, they differentiate and can conduct cross presentation viral peptide antigens obtained by phagocytosis on which of their molecules that can be expressed on their surface? a. MHC class I b. MHC class II c. either MHC class I or MHC class II d. B7 (CD80/86) molecules e. CCR5 How are T cells activated? a. T cell bind their T cell receptors to specific peptide antigen presented on self MHC of APC which initiates signal 1 via the T cell receptor and the co-receptor-associated tyrosine kinases that leads to increasing the release of Ca" from the ER and the increased uptake of Ca" across its plasma membranes to activate the phosphatase calcineurin to remove a phosphate group from inactive NFAT to activate it to travel into the nucleus to induce gene expression that leads to T cell proliferation followed by differentiation into effector b. Activated NFAT migrates to the nucleus to form a complex with AP-1 that induce specific expression of genes for IL-2 and the of IL-2 receptor to form these products which provide signal 3 to facilitate the autocrine activation of the T cell

Explanation / Answer

ANSWERS

60. OPTION C AFFERENT LYMPHATIC VESSELS

61. OPTION E BOTH B AND C ARE CORRECT

62. OPTION B SUBCLAVIAN VEIN

63. OPTION C MHC CLASS II

64. OPTION C ACTIVATION OF SPECIFIC T CELL

65.OPTION B THE SPECIFIC BINDING OF T CELL RECEPTORS

66. OPTION A MHC CLASS I

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