CDS CTL cells arc to use their T cell receptor, to recognize and bind to a speci

Question

CDS CTL cells arc to use their T cell receptor, to recognize and bind to a specific antigen presented on which of the following cell surface molecules of target cells? a. B7 (CD80/86) b. MHC class I c. MHC class II d. MIC-A and MIC-B e. Only choices b and c Severe Combined Immunodeficiency Disease (SOD) can be caused by which of the following? a. Mutations that present thymus development b. Mutation in the TAP (transporter associated with antigen processing) gene c. Mutation in either genes for RAG-1 or RAG-2 d. All of the above answer choices arc correct e. Only answer choices b and c arc correct Virus and other pathogens that replicate in the cytoplasm of human cells use the host cell's translation components to synthesize proteins which can be degraded along with other nonfunctional, self-proteins into small peptide fragments by which cytoplasmic protein structure? a. Proteasomes b. Phagolysosomes c. Mitochondria d. endosomes e. Golgi Peptide fragments produced by the degradation of proteins produced by pathogens in the cytosol of human cells are transported by which of the following into the ER? a. Signal Recognition Particle (SRP). b. SRP docking protein c. TAP 1 and TAP2 d. Transport vesicles e. Golgi The peptide fragments of pathogen proteins and self proteins transported from the cytosol into the ER arc bound to which molecules in the ER? a. B cell receptor b. T cell receptor c. MHC class I d. MHC class II e. Answers c and d are correct The proteins of pathogens that are taken up by phagocytosis into dendritic cells and macrophages are degraded into peptide fragments in which organelle? a. Proteasomes b. Endoplasmic reticulum c. Phagolysosome d. endosomes e. transport vesicles The peptide fragments of pathogens taken up by phagocytosis by dendritic cells, macrophages and B-cells are bound to which of the following for expression on their plasma membranes? a. MHC class I b. MHC class II c. CD80/86(B7) d. CLIP e. HLA-DM Which of the following binds to the cleft of MHC class II in the ER to block the attachment of either self-peptide of pathogen peptides to the MHC class II? a. CLIP b. calreticulin c. HLA-DM d. Calnexin e. HLA-DP Which of the following removes CLIP from MHC class II molecules in the phagolysosomes? a. HLA-DM b. HLA-DO c. HLA-DP d. HLA-DQ e. HLA-DR Which of the following causes clustering of B cell antigen receptors on the plasma membrane to activate the B cell? a. The binding of complement fragment C3d to the plasma membrane of B cells. b. The binding of two or more B cell receptors to the same specific antigen molecule c. Inactive transcriptional factors become activated and induce the expression of genes for specific cytokines d. CD 4 T helper 2 cells activating the B cell by forming a SMAC e. C-reactive protein or Amyloid proteins bind to the plasma membrane of the B cell Which of the following is the principle of clonal selection in adaptive immunity? a. The elimination of B or T lymphocytes that bind to self antigens b. The proliferation of one antigen actuated lymphocyte to produce a clone

Explanation / Answer

answer 75 (b) MHC Class I

answer 76 (d) all choices are correct

answer 77 (a) proteasome

answer 78 (c) TAP 1 & TAP 2

answer 79 (c) MHC Class I

answer 80 (c) phagolysosome

answer 81 (b) MHC Class II

answer 82 (a) CLIP

answer 83 (a) HLA-DM

answer 84 (b) binding of antigen to b cell receptors

85 is not complete.

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