Which of the following are the newer treatments for transplant rejection, and al

Question

Which of the following are the newer treatments for transplant rejection, and allergies? a. Replacement of mutated genes with functional by the use of embryonic stem cells. b. Use of humanized monoclonal antibodies to inhibit a specific part of the immune response. c. Targeting specific cells, neutralizing local excess of cytokines and chemokines and the enhancement natural regulatory T cells (T_ ) mechanisms d. All of the above answers are correct. e. Only answers b and c are correct Why are humanized monoclonal anti-TNF-alpha antibodies effective in treating rheumatoid arthritis? a. They inhibit the adaptive immune response b. They block complement pathways from damaging tissues c. They reduce inflammation. d. All of the above answers are correct e. Only answers b and c are correct The serum of a healthy newborn infant will contain near-adult levels of: a. IgG b. IgM and IgD c. IgG and IgA. e. all Ig isotypes Recombinant DNA technology has been especially useful for the production of which of the following that are used in submit vaccines? a. viral DNA b. viral polysaccharides c. mutated viruses d. viral proteins e. infectious particles Which of the following complicate the development of vaccines to chronic diseases? a. evasion of the host's immune system by the pathogen. b. the polymorphic diversity of MHC class I and class II molecules c. the generation of inappropriate immune responses that do not eradicate the pathogen d. survival of the infectious agent for long periods inside the host and high mutation rates in the pathogen e. All of the above answer choices are correct How can humanized monoclonal antibodies against the Fc of IgE be used against IgE mediated allergies? a. They can act as antagonists by blocking the binding of IgE to mast cells b. They can act as agonists by binding to receptors on mast cells and stimulating the release of inflammatory mediators. c. They can cause systemic shock d. All of the above answers are true e. Only answers a and b are correct Receptors designed for CAR (chimeric antigen receptor) T cells generally have which of the components? a. The extracellular Fe domain that that is targeted by mast cells b. the extracellular domain is the antigen-binding domain of an antibody specific for a tumor-associated antigen. c. An intracellular domain signaling domain of a TNF-receptor or of the CD28 co-stimulatory receptor and a second intracellular domain that consists of three ITAM sequences from the T-cell receptor zeta chain. d. All of the above components e. only answer choices b and c are correct

Explanation / Answer

And 145: The newer treatments for transplant rejection and allergies include: option c

Use of monoclonal antibodies and neutralising excess cytokines can be used as a strategy to overcome transplant rejection.

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