from these data, what cells are required to elicit an autoimmune disease? What c
ID: 80632 • Letter: F
Question
from these data, what cells are required to elicit an autoimmune disease? What cells are required to prevent an autoimmune response? and Why were nude mice used in this study?
7) The nude (nu/nu) mouse does not make a thymus and therefore no maturation of T cells occurs in this animal. To elucidate which, if any, T cells are implicated in generation of autoimmune diseases, nude mice were injected with various T-cell s as indicated below. Three months after injection, the animals were examined for the presence of various autoimmune diseases. The first number shown after treatment is the number of animals found to have an autoimmune disease, the second number is the total number of animals that received that treatment. Treatment 1-uninjected: 0/18 Treatment 2 injected with a mixed population of T cells: 0/10 Treatment 3 injected with T cells that had been depleted of cells containing the marker CD25: 12/12 Treatment 4 injected with T cells that have been depleted of cells containing CD4 and CD25 markers: 0/10 Treatment 5 injected with T cells that have been depleted of cells containing CD8 and CD25 markers: 14/16Explanation / Answer
A type of laboratory mouse that is hairless and lacks a normal thymus gland, and has a defective immune system is called a nude mouse.
It has greatly reduced T cells.They have delayed hypersensitivity reactions and a decreased antibody response to some T- dependant antigens. So they are used in the study.
Removal of CD4CD25 T cells leads to the development of various auto immune diseases.Reconstitution of CD4CD25 T cells prevents the development of auto immune diseases.
CD8 T cells have beneficial effects in auto immune disease.Like CD4 T cells CD8 T cells prevent autoimmune disease.
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