1. Molecular mechanism for SSRI (selective serotonin reuptake inhibitor) and coc

Question

1. Molecular mechanism for SSRI (selective serotonin reuptake inhibitor) and cocaine (or Ritalin) at the synapse:

a. What are the similarities between the molecular mechanism of action of SSRI and Ritalin at the synapse?

b. What are the differences between the molecular mechanism of action of SSRI and Ritalin at the synapse?

c. What are the differences between the disorders treated by SSRI and Ritalin?

d. What are the similarities and differences of the resulting action on the post-synaptic neurons by SSRI

and Ritalin?

2. Compare and contrast ADHD and schizophrenia.

a. What are the similarities between the symptoms of ADHD and schizophrenia?

b. What are the differences between the symptoms of ADHD and schizophrenia?

c. What are the similarities and difference between the neurotransmitter system involved in ADHD and

schizophrenia?

d. What are the different screening tests for ADHD and schizophrenia?

Explanation / Answer

2. a) ADHD (attention deficit hyperactivity disorder) and schizophrenia are two disorders which are similar as these are mental disorders. Symptoms of thought disorder is there in teens, impaired attention; psychotic episodes in schizophrenia as well as present in ADHD patients(10%).

b) Schizophrenia - Hallucinations, social withdrawal, lack focus/attention, confused etc.

ADHD - lack of attention, hyperactivity, impulsive actions etc.

c) Schizophrenia is treated with antipsychotics to block the effect of dopamine while for ADHD there is use of stimulants to increase dopamine level in the brain.

d) few tests doctors can perform to check mental disorder schizophrenia(asking questions, symptoms and by seeing medical history) but for ADHD there is not any specific test to diagnose.

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