What is the purpose of cell-cycle checkpoints, such as the DNA-damage checkpoint

Question

What is the purpose of cell-cycle checkpoints, such as the DNA-damage checkpoint or the spindle-attachment checkpoint? B. You isolate mutant cells defective in the DNA-damage checkpoint, but you find that under normal laboratory conditions, the mutant cells grow and divide at the same rate as wild-type cells. Why doesn't the defect in the DNA-damage checkpoint have a large effect on cell growth and division rates under normal conditions? C. Please describe an experimental condition in which wild-type cells and mutant cells defective in the DNA-damage checkpoint would show a difference in cell growth and division rates. D. How would this condition affect the cell growth and division rates in the wild-type and mutant strains from Part 7B?

Explanation / Answer

a. at various stages of cell cycle the stages are equipped with cell cycle checkpoints, here the cell cycle stops and check the DNA damage and repair it. the major check points are G1, G2 and M phase. thye DNA replication arrest at G2/M phase. whereas the spindle assembly check point is M phase. if these checkpoint working is disturbed, it will lead to mutation and genomic instability resulting in virth defect.

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