In lecture 9 (Chapter 15) we discussed how proteins are translocated to their ta

Question

In lecture 9 (Chapter 15) we discussed how proteins are translocated to their target location/organelle after being folded in the ER. The primary sequence (in one-letter symbol) of a protein is given below. The N-terminal & C-terminal regions are highlighted in blue. Based on your understanding about various types of signaling sequences that direct proteins to their destinations, determine where this protein will be translocated to and WHY? What does normally happen to the signaling sequence after the protein is properly translocated to its destination? Explain your answer.

Explanation / Answer

The protein will be destined for secretion by the secretary pathway. It consists of a small stretch of hydrophobic amino acids at the N-terminus after 11 aminoacids. The protein is destined for extracellular secretion, the plasma membrane, ER, Golgi or endosomes.

The signal peptide is often cleaved off after it reaches its destination by the signal peptidase.

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