Also in contrast to the E. coli circular chromosome is the fact that eukaryotic

Question

Also in contrast to the E. coli circular chromosome is the fact that eukaryotic chromosomes are not circular, but instead are __4__. Eukaryotic chromosomes are complexed heavily with protein to form a DNA-protein complex generically called __5__. The proteins found can be considered to fall into two general classes: __6__ and __7__. The first class is made up of 5 major proteins called __8__, __9__, __10__, __11__, and __12__. On a weight to weight basis, these proteins make up about __13__% of the total mass of a chromosome. Since these proteins must associate relatively non-specifically with DNA, they are rich in the basic amino acids __13__ and __14__, which gives the proteins a net __15__ charge. Also in contrast to the E. coli circular chromosome is the fact that eukaryotic chromosomes are not circular, but instead are __4__. Eukaryotic chromosomes are complexed heavily with protein to form a DNA-protein complex generically called __5__. The proteins found can be considered to fall into two general classes: __6__ and __7__. The first class is made up of 5 major proteins called __8__, __9__, __10__, __11__, and __12__. On a weight to weight basis, these proteins make up about __13__% of the total mass of a chromosome. Since these proteins must associate relatively non-specifically with DNA, they are rich in the basic amino acids __13__ and __14__, which gives the proteins a net __15__ charge.

Explanation / Answer

Also in contrast to the E. coli circular chromosome is the fact that eukaryotic chromosomes are not circular, but instead are linear. Eukaryotic chromosomes are complexed heavily with protein to form a DNA-protein complex generically called chromatin. The proteins found can be considered to fall into two general classes: histone proteins and non-histone proteins. The first class is made up of 5 major proteins called H1, H2A, H2B, H3, and H4. On a weight to weight basis, these proteins make up about 30% of the total mass of a chromosome. Since these proteins must associate relatively non-specifically with DNA, they are rich in the basic amino acids arginine and lysine, which gives the proteins a net negative charge.

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