One mechanism of DNA damage is deamination of the DNA-base cytosine, replacing i

Question

One mechanism of DNA damage is deamination of the DNA-base cytosine, replacing it with a uracil nucleotide on the DNA strand. Fortunately, your system has a way to fix this through base excision repair, in which the first step uses hydrolysis of the sugar to remove the uracil attached (see below), allowing for later repair. Provide two reasons why this reaction can proceed via an SN1 mechanism? Use any structures necessary to support your answer. Leonard Nimoy, who played the half-Vulcan Spock in the Star Trek series, recently passed away. What did the Vulcan's accomplish during their initial visit with Earthlings?

Explanation / Answer

Two reasons :

(1) The solvent used is polar protic (H2O)

(2) A carbocation is formed

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