26. Which of the following is not true of miRNA processing? (a) Drosha processes

Question

26. Which of the following is not true of miRNA processing?

(a) Drosha processes primary miRNA transcripts to precursor miRNAs.

(b) RISC binds to pre-miRNA in the cytoplasm.

(c) RNA helicase is necessary for unwinding the miRNA duplex.

(d) Dicer completes the processing by cleaving the single-stranded form of the miRNA.

27. Which of the following is not a function of the RNA-induced silencing complex (RISC)?

(a) primary miRNA transcript conversion to precursor miRNA

(b) cleavage of precursor miRNA to short duplex miRNAs

(c) facilitation of base pairing between mature miRNA and its complementary sequence in an mRNA

(d) cleavage of the mRNA transcript targeted by siRNA

28. RNAi probably evolved as a mechanism to:

(a) aid molecular biologists to experimentally knock down gene expression.

(b) catalyze RNA-dependent DNA synthesis.

(c) suppress infection by RNA viruses.

(d) generate cell-specificity for certain mRNAs.

Explanation / Answer

26. c

There is no unwinding of the miRNA duplex in miRNA processing.

27. a

Primary miRNA transcripts are converted to precursor miRNA by Drosha not by RISC.

28. c

RNAi has an important role in defending cells against viruses, post-transcriptional gene regulation and transposon silencing.

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