R. U. Serious is a marathoner who decides training outdoors in the winter is a g

Question

R. U. Serious is a marathoner who decides training outdoors in the winter is a good way to get a leg up on the competition. She also believes in thorough checkups because of kidney dysfunction when she runs a marathon. Test results show renal failure with a reduction in GFR, increases in serum potassium and decreases in serum sodium. Why would her body respond this way to a run? Finally at the age of 64 years she sometimes has to deal with occasional constipation. Why would she have to deal with that problem with proper diet and exercise? R. U. Serious is a marathoner who decides training outdoors in the winter is a good way to get a leg up on the competition. She also believes in thorough checkups because of kidney dysfunction when she runs a marathon. Test results show renal failure with a reduction in GFR, increases in serum potassium and decreases in serum sodium. Why would her body respond this way to a run? Finally at the age of 64 years she sometimes has to deal with occasional constipation. Why would she have to deal with that problem with proper diet and exercise?

Explanation / Answer

This happens because myoglobin is present in the muscles and helps in utilisation of oxygen by the muscles. Myoglobin is prevalent in trained athletes who exercise for long durations. During such heavy running or marathon, which is not regular for her, if a muscle breaks down or gets injured in some way, this myoglobin would get leaked into the blood and would get carried in the kidney. This results in renal failure or kidney failure by

- tubular obstruction or some toxic reaction

- decreased supply of oxygen to the kidneys

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