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If an X-linked disease results from a rare recessive allele, all sons of affecte

ID: 81663 • Letter: I

Question

If an X-linked disease results from a rare recessive allele, all sons of affected males will be affected among females there will be more affected than carriers there will be more females exhibiting the trait than males there will be more males exhibiting the trait than females the frequency of affected males and females will be equal If an X-linked disease results from a rare recessive allele, all sons of affected males will be affected among females there will be more affected than carriers there will be more females exhibiting the trait than males there will be more males exhibiting the trait than females the frequency of affected males and females will be equal If an X-linked disease results from a rare recessive allele, all sons of affected males will be affected among females there will be more affected than carriers there will be more females exhibiting the trait than males there will be more males exhibiting the trait than females the frequency of affected males and females will be equal

Explanation / Answer

If an X-linked disease results from a rare recessive allele, There will be more males exhibiting the trait than females.

Most X-linked conditions are recessive. This means that in a person with two X chromosomes (most females), both copies of a gene (i.e., one on each X chromosome) must have a change or mutation whereas in a person with one X chromosome (most males), only one copy of a gene must have a mutation. A female with a mutation in one copy of a gene on the X chromosome is said to be a “carrier” for an X-linked condition. A male with a mutation in a gene on the X chromosome is typically affected with the condition. Because females have two copies of the X chromosome and males have only one X chromosome, X-linked recessive diseases are more common among males than females. However, X-linked recessive diseases can occur in both males and females.

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