The pedigree below shows the inheritance pattern for one gene involved in eye co

Question

The pedigree below shows the inheritance pattern for one gene involved in eye color within a particular family. The loss-of-function, recessive allele affects the amount of melanin in the eye, but one copy of a functional allele results in brown eyes. The loss of function, recessive allele is not rare within the population. Those with filled in circles and squares have lighter colored eyes. Identify all of the individuals who must be carriers in the pedigree below. I II III IV II-1 II-2 II-3 II-4 III-1 III-2 III-3 III-4 III-5

Explanation / Answer

Must be Carrier:

I-2

II-2, II-3, II-4

III-1, III-2,

Explanation:

two copies of a disease allele are required for an individual to be susceptible to expressing the phenotype

Both parents have to carry the allele for the offspring to be affected

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