The transplant of a baboon heart into a human neonate (at Loma Linda, CA) was de
ID: 82446 • Letter: T
Question
The transplant of a baboon heart into a human neonate (at Loma Linda, CA) was designed to prove the existence of positive selection. proved the existence of negative selection. would never be possible because of self-nonself discrimination. failed because of GVH. ended due to failure of non-immunological organ systems. proved inconclusive for xenogeneic transplantation into humans. indicate nothing regarding any of the above. An individual may fail to make any antibody to a polypeptide with a single antigenic determinant because she lacks appropriate MHC class II molecule. her macrophages can not process the antigen. she does not have B cells in her repertoire capable of recognizing that particular determinant. she does not have T cells in her repertoire capable of recognizing that particular determinant. effector B cells and helper T cells must recognize different effector and helper determinants on the same antigen. she lacks appropriate MHC class I molecule. That is impossible- everyone makes immune responses to all antigens,Explanation / Answer
9. 6. Proved inconclusive for xenogenic transplantation into humans.
The baby died 21 days later of heart failure due to rejection of the transplant. The rejection is thought to have been caused largely by a humoral response against the graft, due to Fae's type O blood creating antibodies against the type AB xenograft.
10. C. She does not have B cells in her repotoire capable of recognizing that particular determinant.
Antibodies are produced by B cells and not T cells and since body is unable to produce antibody against particular antigenic determinant, it suggests B cells are unable to recognize that antigen.
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