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Which of the following soluble second messengers could activate signal transduct

ID: 82501 • Letter: W

Question

Which of the following soluble second messengers could activate signal transduction processes in the cytoplasm? Choose all that apply. There are 3 correct answers. You will LOSE points (from the total correct for incorrect answers. This is to discourage guessing. PIP2 PKA IP3 DAG calcium cAMP If you could inhibit the action of _____, the spindle poles would stop moving apart. Choose all that apply. There are 2 correct answers. You will LOSE points (from the total correct) for incorrect answers. This is to discourage guessing.

Explanation / Answer

Second messengers are the substances that enter the cytoplasm and act within the cell to trigger a response and serve as chemical relays from the plasma membrane to the cytoplasm, thus carrying out intracellular signal transduction.

The correct answer is

IP3 and cAMP; Most intracellular proteins activated by a receptor interaction possess an enzymatic activity; Often such enzymes are covalently linked to the receptor and create second messengers such as cyclic AMP and IP3, the latter controlling the release of intracellular calcium stores into the cytoplasm. Other activated proteins interact with adaptor proteins that facilitate signalling protein interactions and coordination of signalling complexes necessary to respond to a particular stimulus.

Calcium; The release of calcium ions from the endoplasmic reticulum into the cytosol results in its binding to signaling proteins that are then activated; it is then sequestered in the smooth endoplasmic reticulum and the mitochondria.

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