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Why is it tolerable that the error frequency in RNA synthesis is 10 4 - 10 6 tim

ID: 83581 • Letter: W

Question

Why is it tolerable that the error frequency in RNA synthesis is 104 - 106 times higher than that for DNA synthesis?

Because most genes are transcribed many times, most nucleotide substitutions will lead to amino acid substitutions, and amino acid substitutions in proteins are often functionally innocuous.

Because most genes are transcribed many times, but not all nucleotide substitutions will lead to amino acid substitutions, and amino acid substitutions in proteins are seldom functionally innocuous.

Because most genes are transcribed only once, but not all nucleotide substitutions will lead to amino acid substitutions, and amino acid substitutions in proteins are often functionally innocuous.

Because most genes are transcribed many times, but not all nucleotide substitutions will lead to amino acid substitutions, and amino acid substitutions in proteins are often functionally innocuous.

Because most genes are transcribed many times, most nucleotide substitutions will lead to amino acid substitutions, and amino acid substitutions in proteins are often functionally innocuous.

Explanation / Answer

The correct answer is D "Because most genes are transcribed many times, but not all nucleotide substitutions will lead to amino acid substitutions, and amino acid substitutions in proteins are often functionally innocuous"

The error frequency in RNA synthesis is 104 to 106 times higher than that for DNA synthesis, is tolerable because most genes are repeatedly transcribed, because the genetic code contains numerous synonyms, and because amino acid substitutions in proteins are often functionally innocuous. Also, not all nucleotide sequence substitutions lead to amino acid substitutions in protein-coding genes.

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