These questions have been asked and answered here twice, but each set of answers
ID: 836438 • Letter: T
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These questions have been asked and answered here twice, but each set of answers was different, so it's hard to know which is correct. Could someone rank the reactivities and give me answers that are a few sentences long for questions 2 and 3? Thanks!
For an aldol reaction, the key step is the attack on the partially positive carbonyl carbon by a nucleophile. Rank the following benzaldehydes by their reactivity in an aldol reaction: (l=most reactive, 3=least reactive). Why doesn't this aldol reaction make multiple major products even though there are two carbonyl compounds in the reaction? Why do you only obtain the trans isomer as the product for these reactions?Explanation / Answer
1-The reactivity order is 1<2<3 because NO2 and OCH3 are EWG groups which make the Carbon atom in the carbonyl group more electropositive
2-Because the attack of nucleophile predomonantly occurs at more electrophilic carbon so more is the electrophile the carbon more will be the product.so aldol reaction doesn't form multiple major products
3-Due to steric interaction of Nucleophile with the carbonyl group it always attack from the back side which leads to trans isomer product
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