Citrate synthase, one of the enzymes in the series of enzyme-catalyzed reactions

Question

Citrate synthase, one of the enzymes in the series of enzyme-catalyzed reactions known as the Krebs cycle, catalyzes the synthesis of citric acid from oxaloacetic acid and acetyl-CoA. If the synthesis is carried out with acetyl-CoA that has radioactive carbon C4in the indicated position, the isomer shown here is obtained. Which stereoisomer of citric acid is synthesized, R or S? Why is the other stereoisomer not obtained? If the acetyl-CoA used in the synthesis does not contain will the product of the reaction be chiral or achiral? (1+2+2= 5points)

Explanation / Answer

1. S-Isomer

2.only one configaration is possible based on proirity order of OH,COOH,CH2COOH last one is prefered for out of plane one

3.achiral

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