Can you answer the following? Gradebook O 5/16/2017 11:55 PM A 76.2/100 5/15/201

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Can you answer the following?

Gradebook O 5/16/2017 11:55 PM A 76.2/100 5/15/2017 05:55 PM Print Calculator Periodic Table Question 11 of 13 Map pling Learning Lysosomes are membranous organelles that contain digestive enzymes. Lysosomes can function inside the cell, where their enzymes digest particles taken in by endocytosis or worn-out cell components Lysosomes can also release their enzymes outside the cell, where the enzymes break down extracellular material Answer the following questions about conditions related to lysosomal function. Wolman disease is a lysosomal storage disease that results in the buildup of lipids (fats) in the spleen, liver, bone marrow, small intestine, adrenal glands, and lymph nodes. Which is the probable cause? O The Golgi apparatus delivers lipid-digesting enzymes to the lysosome, which destroy it. O Lysosomes accumulate extra lipid-digesting enzymes. O A gene mut results in a shortage of lipid-digesting enzymes in the lysosome. ation O The cell does not take up lipid molecules by endocytosis. Rheumatoid arthritis (RA) is an autoimmune disease marked by inflammation and cartilage destruction. Although the causes are not known, it may be linked to lysosomal proteases (protein-digesting How be to RA? O Cells produce defective lysosomal proteases, which break down proteins inefficiently. O Chondroblasts (cells in cartilage) sequester collagen-building enzymes within lysosomes. O The lysosomes in cartilage tissue cannot fuse with protein-containing vesicles Excess lysosomal proteases are produced and released extracellulary, where they degrade collagen O Previous Give Up & View Solution Check Answer Next Ext Hint

Explanation / Answer

Answer a) A gene mutation results in a shortage of lipid-digesting enzymes in the lysosome.

Wolman disease is a lysosomal storage disease that is caused by the mutation in the LIPA gene. LIPA gene produces a lysosomal acid lipase enzyme present in the lysosomes. This enzyme is responsible for the digestion and recycling of the waste materials in the cell. It causes the breakdown of lipids such as triglycerides and cholesteryl esters.

Answer b) Excess lysosomal proteases are produced and released extracellularly, where they degrade collagen.

Rheumatoid arthritis results in the release of lysosomal enzymes such as proteases into the extracellular matrix which are responsible for the degradation of the collagen present in the surrounding tissues. Lysosomal proteases are the hydrolytic enzymes which causes the breakdown of amino acids. Collagen is made up of 19 amino acids, predominantly glycine, proline, and hydroxyproline.

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