A chemical compound is not mutagenic at all its native form, but gets converted

Question

A chemical compound is not mutagenic at all its native form, but gets converted by liver eniymes into a compound that causes excessive chemical mutations. If this compound is tested using the Ames test, ___ bacterial colonies will form when this compound is incubated with a his-bacterial strain WITHOUT liver enzymes before plating on an agar plate that is lacking the amino acid histidine. This compound would probably be ___ to include in cosmetic products for skin A) no or very few;safe B) many;safe C) no or very; unsafe D) many;unsafe E) not enough information to determine Excessive exposure to harmful UV rays usually results in which of the following types of DNA modification? A) Single base transitions B) Single base transversions C) deamination of DNA D) depurination of DNA E) thymine dimer formation Insertion and deletion mutation can be caused by which of the following? A) strand slippage during replicaton B) unequal crosing over C) depurination D) A and B E) A, B, and C When strand slippage occurs during DNA replication, if looped-out nucleotide occur in the newly synthesized strand, a(n) ___ mutation results A) translocation B) insertion C) deletion D) transversion E) none of the above If crossing over occurs between 2 homologous chromosomes that are misaligned, what is the consequence in the resulting recombined chromosomes? A) both chromosomes will have a deletion B) both chromosomes will have an insertion/duplication C) One chromosomes will have a duplication/insertion and the other will be unaffected D) One chromosomes will have a deletion, and the other will be unaffected E) One chromosomes will have an insertion/duplication and the other will have a corresponding deletion ____ does not replace nucleotides, but changes them back into their original form. A) mismatch repair B) direct repair C) base-excision repair D) nuceotide excision repair The mismatch repair system detects mutations in newly replicated DNA. The proteins in this system are able to distinguished between the newly synthsized and original template strands, because the ___ strand is ___ at GATC sequences, but the ___ strand is not? A) newly synthesized; mehtylated; original template B) original template; methylated; newly synthesized C) newly synthesized; acetylated; original template D) original template;acetylated;newly synthesized Freckle-like spots on skin, hypersensitivity to sunlight, and predisposition to skin cancer are all traits associated with human disorder xeroderma pigmentosum, this condition results from which of the following? A) Tetrasomy 8 B) a deletion in a gene on the hort arm of chromosomes 17 C) a mutation in one or more genes that affects DNA repair D) a mutation in one or more genes that affects cell division E) None of the above

Explanation / Answer

48
THE ANSWER IS C. A MUTATIONIN ONE OR MORE GENES THAT AFFECTS DNA REPAIR.

EXPLANTION
It is a rare autosomal recessive genetic disorde, it is due to DNA repair in which the ability to repair damage caused by UV light is deficient.

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