Pyruvate kinase catalyzes the transfer of a phosphoryl group from phosphoenolpyr

Question

Pyruvate kinase catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP in the last step of glycolysis, forming pyruvate in the process. Vertebrates have several isozymes of pyruvate kinase, which can be allosteric ally inhibited by compounds including ATP and acetyl-CoA, What is an effect of cAMP-dependent protein kinase (PKA) inactivation of the liver isozyme but not the muscle isozyme? Glycogen synthesis is promoted in the liver as an energy store. Glycolysis is inhibited in the liver, but not muscle, when blood sugar is low. Under stress (fight-or-flight) conditions, the liver can use glycolysis to break down glucose. Phosphate from the dephosphorylation of the liver isozyme is used to generate ATP and provide energy for movement.

Explanation / Answer

ANS: Glycolysis is inhibited in liver but not muscle,when blood sugar is low.

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