Hydroxylation of lysine and proline yields hydroxylysine and hydroxyproline. The
ID: 85228 • Letter: H
Question
Hydroxylation of lysine and proline yields hydroxylysine and hydroxyproline. These modified amino acids (AA) maintain the strength and structure of collagen. Albert is working in the research lab, and has been tasked to develop a short new synthetic protein 20 AA long, from scratch. He has already synthesized the sequence for the first 17 amino acids of the protein, but is unsure of the remainder of the sequence. Knowing that hydroxylation of only lysine and proline is possible under his set conditions, how many different protein sequesnces of the appropriate length can be synthesized using Albert’s 17 AA starting block.
Explanation / Answer
Answer:
There rae 6 different possible sequences which could occur. Hydroxyproline(HP) and Hydroxylysine(HL) can make !3= 6 different combinations on last three position.
HL-HP-HL, HL-HL-HP, HP-HP-HP, HL-HL-HL, HP-HL-HP, HP-HP-HL
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