The following fractional saturation data have been measured for a certain blood

Question

The following fractional saturation data have been measured for a certain blood sample. On a piece of graph paper, plot out the data in a Hill plot. What are the Hill constant and the p50 of this blood sample?

The following fractional saturation data have been measured for a certain blood sample. On a piece of graph paper, plot out the data in a Hill plot. What are the Hill constant and the p50 of this blood sample?

The following fractional saturation data have been measured for a certain blood sample. On a piece of graph paper, plot out the data in a Hill plot. What are the Hill constant and the p50 of this blood sample?

Explanation / Answer

for the top row (PO2) make a new chart with the log(PO2) values. for the second row, plug in (YO2/1-YO2) for each value. here will be the new chart you'll use to make the graph:

now make a graph with these numbers. the top row will be the x axis and the bottom row will be the y axis.

--> Hill constant(n) : slope=2.9007

--> p50: you can get this value from the x intercept. since the x intercept is log(p50)=1.8 you need to isolate p50 by plugging in 10^1.8 into your calculator which turns out to be 63.1 torr

Log (PO2) 1.54 1.65 1.74 1.81 1.88 1.93 Log (YO2/1-YO2) -0.865 -0.477 -0.213 0.035 0.140 0.269

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