Citric acid (citrate) is justifiably well known as part of the citric acid cycle

Question

Citric acid (citrate) is justifiably well known as part of the citric acid cycle. But citrate has very important roles in fatty acid synthesis. Which of the following is a role of citrate in fatty acid synthesis?

A. Within the mitochondrion, citrate, as a component of the citric acid cycle, provides the NADPH required for fatty acid synthesis.

B. Citrate moves from mitochondria into the cytosol where it is used directly to elongate growing fatty acid chains.

C. Citrate in the cytosol reactions with NADH to provide NADPH for fatty acid synthesis.

D. In the cytosol, citrate is cleaved by HSCoA to produce oxaloacetate (which leads to NADPH synthesis) and acetylCoA (which is used to extend growing fatty acid chains).

Explanation / Answer

D. In the cytosol, citrate is cleaved by HSCoA to produce oxaloacetate (which leads to NADPH synthesis) and acetylCoA (which is used to extend growing fatty acid chains).

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