In terms of changes in functional groups, the first three beta oxidation reactio

Question

In terms of changes in functional groups, the first three beta oxidation reactions (starting with an oxidation that uses FAD as cofactor) are fully analogous to which three reactions in the citric acid cycle? (I'll just use numbers for the CAC reactions; as in Table 19.1)

A. Reactions 1 - 3

B. Reactns 4 - 6

C. Reactions 8 - 2

D. Reactions 6 - 8

Imagine an acylCoA with a fatty acyl group of length 14 (and unsaturated) feeding into the beta oxidation pathway. What would be the products of complete processing of this acylCoA by this pathway?

A. 7 acetylCoA; 7 NADH; 7 FADH2

B. 8 acetylCoA; 7 NADH; 7 FADH2

C. 7 acetylCoA; 6 NADH; 6 FADH2

D. 6 acetylCoA; 6 NADH; 6 FADH2

We all know that carbohydrate cannot be synthesized from "fat" in the diet -- whereas, "fat" (triacylglycerols) certainly can be synthesized from carb (!).

More accurately, carbohydrates such as glucose cannot be synthesized from fatty acids.

Why is this statement true? This is discussed explicitly in your text.

A. AcetylCoA from beta-oxidation cannot enter the citric acid cycle.

B. NADH from beta-oxidation could not be used as reducing power in gluconeogenesis.

C. The synthesis of aceylCoA from pyruvate is metabolically irreversible -- thus, pyruvate cannot be synthesized from acetylCoA and CO2.

D. All of the above are reasons why glucose cannot be synthesized from fatty acids

Explanation / Answer

1) The products of the complete processing of the beta oxidation of acylCoA are 7 acetylCoA; 6 NADH; 6 FADH2.

Thus, the correct option is C

2) The synthesis of aceylCoA from pyruvate is metabolically irreversible -- thus, pyruvate cannot be synthesized from acetylCoA and CO2.

Thus, the correct option is C

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