The criteria for acceptable biological and biochemical buffers were established

Question

The criteria for acceptable biological and biochemical buffers were established by studies conducted by Norman Good et al. in 1966. These criteria included a pKa within physiological range soluble in water membrane impermeability minimal salt effect minimal temperature and concentration effects on dissociation minimal interactions with cations chemical stability no/minimal, or well-documented, UV light absorbance at certain wavelengths easy to prepare Choose the buffer characteristic that fails to meet the criteria. Choose the best answer given the information. Acetate buffer; Michaelis buffer ineffective near physiological pH influence of temperature on dissociation is too high minimal solubility in water easily passes through cell membrane TRIS; Tris(hydroxymethyl)aminomethane ineffective near physiological pH influence of temperature on dissociation is too high minimal solubility in water soluble in nonpolar solvents

Explanation / Answer

1. ineffective near physiological pH.

Body pH is slightly above 7, at which the buffer is nearly ineffective.

2. Influence of temperature on dissociation is too high.

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