34. The following type of mutat na protooncogene may cause cancer in human A) ge

Question

34. The following type of mutat na protooncogene may cause cancer in human A) gene B) Gene amplification Point mutation within regulatory element, D) Point mutation within gene E) All of the above he following statement is true about a tumor suppressor gene mutation to induce cell divisior 3s. mammalian cell: A) Proto-oncogene product must have decreased activity, B) Tumor suppressor gene product must lose activity. C) Tumor suppressor gene product must have an increased activity. D) Proto-oncogene must lose ability to express mRNA, 36. Incidence of cancer in human increases with age suggesting that: A) Cancer is an infectious disease. B) Multiple mutations are required to develop cancer. Cancer gene(s) cannot be acquired in lifetime. D) None of the above are 37. Which of the following is true concerning cancer cells? A) They do not exhibit density-dependent inhibition when growing in culture. B) When they stop dividing, they do so at random points in the cell cycle. C) They are not subject to cell cycle controls. D) B and C only E) A, B, and C 38. miRNA is synthesized by which RNA polymerase: A) I B) II D) None of the above 39. study the nucleotide sequences of wild type and it's mutant gene below. Wid type: Mutant: Protein: Met Pro-Glu. Pro- Lys- Met Met ATG CCCAAA -Lys Met CCCAAA ATG DNA. DNA ATG COCGA CCCAAA AIG This mutation can best be called: A) Non-sense B) silent Frameshift D) Mis-sense E) All of the above

Explanation / Answer

34 ans-E-all of the above

Conversion, or activation, of a proto-oncogene( not-yet-mutated forms ) into an oncogene (cancer-promoting forms) generally involves a gain-of-function mutation and an increase in protein (enzyme) activity.Gene amplification of a DNA segment leading to overexpression of the encoded protein and Chromosomal translocation also leads to higher expression of protein which cause the cancer in human.

35 ans-B-tumour suppressor gene product must lose activity

Loss of one or more of these in TSG gene are contributes to the development of many cancers.

36 ans-B multiple mutations are required to develop cancer

For ex.-  insertions and deletions,karyotypic abnormalities and very frequent allelic loss etc

37 ans-E-A,B,AND C

Cancer cells elude normal regulation and divide out of control, forming tumors. lack of density-dependent inhibition and anchorage dependence, cancer cells do not stop dividing when growth factors are depleted

38 ans-B-ii

mi RNA is generally transcribed by  RNA polymerase II (Pol II).The polymerase binds to a promoter near the DNA sequence, encoding hairpin loop of the pre-miRNA.

Related Questions

Navigate

• Browse (All)
• Browse 3
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.