NEW PAINKILLER ON THE BLOCK Although morphine and aspirin are effective at dulli
ID: 876015 • Letter: N
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NEW PAINKILLER ON THE BLOCK Although morphine and aspirin are effective at dulling pain, they come with consequences. For instance, morphine can be addictive. And aspi- rin can cause gastrointestinal bleeding. Searching for painkillers without these side effects, a research team led by Daria Mochly-Rosen of Stanford University School of Medicine has hit upon one compound, called Alda-1, that might fit the bill (Sci. Transl. Med 2014, DOl: 10.1126/scitranslmed.3009539) Alda-1 enhances the activity of aldehyde dehy drogenase-2, an enzyme whose job it is to break down potentially harmful aldehydes in the body into innocuous acids. The researchers genetically engineered mice to produce a defective version of the enzyme and then injected the rodents' paws with inflammatory chem icals. Not only did the paws accumulate aldehydes such as 4-hydroxynon enal, but the mice also exhibited a lower tolerance to pain. When the team gave Alda-1 to these mice and to normal mice, both sets displayed an increased pain threshold. All the animals benefited from Alda-1, Mochly- Rosen says, because the compound fixes the aldehyde dehydrogenase-2 defect in the engineered mice and boosts the enzyme's activity in normal mice. The team will next study whether Alda-1 is effective against types of pain other than acute inflammation.-LKW Alda-1 Read the article above and then do the following A) Draw the skeletal structure of the molecule that accumulated in the paws of the mice given that the double bond is between carbons 2 and 3 and has the (E)-configuration. B The name given in he article is not he preferred name since that nar e ambiguity. es not cate the double bond or indicate the configuration. Rewrite the arm ti compound incorpora i Oti tneses hatte C) Alda-1 appears to enhance the aivity of an enzyme. This enzyme's job is to convert (via oxidation) harmful aldehydes to what functional group? Those of you interested in the phenomenon known as "Asian flush" may find the reports on Alda-1 interesting (see what you find when you "google" Alda-1)Explanation / Answer
3) O=C2C=CCC1
2)
o=C2C(CCC2)=C/CCC3
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