describe and explain the possible effect on your results of the following experi
ID: 876246 • Letter: D
Question
describe and explain the possible effect on your results of the following experimental variations or errors. (A) the reagent bottle labeled "sodium saccharin" contained saccharin instead. (B) you used water as the reaction solvent rather than DMF. (C) you heated the reaction mixture for 3 hours under reflux. Reaction of lodoethane with Sodium Saccharin, an Ambide Reaction. Carry out the reaction under the hood. Weigh 10.0 mmol of sodium saccharin and add it to 5.0 mL of N,N-dimethylformamide in a 125-mL Erlenmeyer flask. Heat the mixture in an 80°C water bath with swirling until the solid dissolves, and then add 0.80 mL (~10 mmol) of io- doethane using a dispenser or an automatic pipet. Cover the mouth of the flask with Parafilm and heat the mixture in the water bath with occasional swirling for 10 minutes; keep the water temperature close to 80°C during this period. Separation. Let the reaction mixture cool to room temperature, add 40 mL of water, and shake the stoppered flask until any liquid residue that forms has solidified. Cool the flask in an ice/water bath and break up the solid with a spatula or stirring rod until it is finely divided. Collect the solid by vacuum filtration [OP-16], washing it twice with 5-mL portions of ice- cold water [OP-26a]. Dry [OP-26b] the product but do not taste it! Analysis. Measure the mass and melting-point range [OP-33] of the product. Record an integrated 'H NMR spectrum [OP-40] of the product in deuterochloroform or obtain one from your instructor. At your instruc- tor's discretion, you can analyze the product mixture by HPLC [OP-38: the instructor will demonstrate the operation of the instrument. If the product is a single compound, deduce its identity. If it is a mixture, calcu- late its percentage composition and decide whether N-ethylsaccharin or O-ethylsaccharin is the major product. Exercises 1. (a) Assuming that the reaction was Sy2, which atom appears te be mereExplanation / Answer
Sodium saccharin is a salt of sachharin which is neutral and can undergo any kind of reaction easily rather than only saccharin.
N,N-dimethylformamide is used because it is a high boiling organic solvent and as we know our compound is also organic and like dissolves like concept is there.Hence the favourable solvent for our compound is DMF rather than water which is an aqueous solvent.
DMF has a very high boiling boint so to reflux very high temperature condition for longer time will be required.
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