18.24 Drug formulations contain an active drug dissolved in a nontoxic solution

Question

18.24 Drug formulations contain an active drug dissolved in a nontoxic solution to facilitate its delivery into the body. They are often packaged into sterile syringes so that the patient can inject the drug formulation directly into the body and then throw the syringe away. Often the drug-loaded syringes arc shipped by air freight to customers. There is a concern that the low temperatures associated with air freight cargo holds might promote the precipitation of the drug from solution. A certain monoclonal antibody is known to precipitate from its delivery solution at 2 degree C. The cargo hold in the airplane used by the air freight company is maintained at O'C. Initially, the syringe is at a uniform temperature of 25 degree C. Within the current packaging environment of the syringe, the convective heat-transfer coefficient of air surrounding the syringe is 0.86 W/m2 . K. The barrel of the syringe containing the liquid is 0.70 cm inner diameter and 8cm in length. The thermal conductivity of the solution is 0.3 W/m . K, the density is I g/cm3 and heat capacity is 2000.1/kg . K. The syringe wall is very thin. If the air flight is 3.5 hr in length. will the drug completely precipitate and ruin the product?

Explanation / Answer

Under the conditions given in the above shown problem, the drug will precipitate out easily and completely.

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