Which of the following combination of events are associated with activation of t

Question

Which of the following combination of events are associated with activation of the beta-adrenergic receptor pathway? I. Binding of an antagonist. II. Binding of an agonist III. Ligand-induced membrane spanning conformational changes. IV. Ligand-induced conformational changes that occur only in extracellular region of the receptor V. An increased association between the receptor protein and G protein. VI. An increased dissociation between the receptor protein and G protein. VII. Association of multiple subunits to form a trimeric G protein. VIII. Dissociation of the trimeric G protein IX. Conversion of G_alpha(GDP) to G_alpha(GTP). X. Conversion of G_beta(GDP) to G_beta(GTP). A. I, III, VI, VIII, & IX B. II, III, VI, VIII & IX C. II, IV, VI, VIII, & IX D. II, III, VI, VIII, & X E. II, III, V, VII, & XI

Explanation / Answer

Answer= The combination of events that takes place with the activation of beta adrenergic receptor are

B] II ,III,VI,VIII,IX

II] Binding of an agonist = agonist is a signaling molecule binds to its receptor & causing the normal response are called as agonist

III] Ligand induced membrane spanning conformational changes = binding of an agonist to G protein coupled receptor induces conformational change in the receptor

VI] An increased dissociation between receptor protein & G protein=

VIII] Dissociation of the trimeric G protein= in inactive state G protein complex is in inactive state.i.e.GDP bound form .on activation of G -protein complex it results in exchange of GDP withGTP on alpha subunit ,after which alpha & beta gamma dissociate

IX]conversion of G aplha GDP to G alpha GTP =  in inactive state G protein complex is in inactive state.i.e.GDP bound form .on activation of G -protein complex it results in exchange of GDP withGTP on alpha subunit ,after which alpha & beta gamma dissociate

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