All of the drug candidates listed below failed to make it to the market. Indicat

Question

All of the drug candidates listed below failed to make it to the market. Indicate point in the drug discovery/development pipeline that the drug candidates probably failed.

a) A cholesterol lowering drug candidate was found to lead to a high incidence of breast tumors in women.

b) An anti-hypertension drug candidate was found to lower blood pressure in non-human primates but was only effective in humans at high doses.

c) An antidepressant drug candidate was found to cause nausea and vomiting in 80% of people that tried the drug.

d) An antibiotic drug candidate was found to have a therapeutic index of 1.5.

e) A smoking cessation drug was determined to be too costly to produce in order to compete with existing drugs on the market.

Explanation / Answer

The point of drug failurewould possible be,

a) For a cholesterol lowering drug candidate found to lead a high incidence of breast cancel women would possible be during the implementatin stage [final stage]

b) An anti-hypertension drug candidate was found to lower blood pressure in non-human primates but was only effective in humans at high doses failed at the clinical trial stage.

c) An anti-depressant drug candidate was found to cause nausea and vomitting in 80% of people that tried the drug failed at the clinical stage testing.

d) An antibiotic drug candidate was found to have a therapeutic index of 1.5 failed at the post implementation stage for the drugs in the market.

e) A smoking cessation drug was determined to be too costly to produce in order to compete with existing drugs on the market failed at the production stage, that would be the first stage.

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