The synthesis of the activated form of acetate (acetyl- CoA) that enters the Kre

Question

The synthesis of the activated form of acetate (acetyl- CoA) that enters the Krebs cycle is carried out in an ATP-dependent process:

Acetate + CoA + ATP èacetyl-CoA + AMP + PPi

If the G° for the hydrolysis of acetyl-CoA to acetate and CoA is -7.69 kcal/mol and that for hydrolysis of ATP to AMP and PPi is -7.29 kcal/mol. What is G° for the ATP- dependent synthesis of acetyl-CoA?
a) -14.98 kcal/mol       b) + 0.4 kcal/mol         c) -0.4 kcal/mol           d) +14.98kcal/mol       e) 0 kcal/mol

I need a detailed explanation on how the answer is found please for my studies!

Explanation / Answer

Acetate + CoA + ATP -----> acetyl-CoA + AMP + PPi

G° for the hydrolysis of acetyl-CoA to acetate and CoA is -7.69 kcal/mol

G° for the hydrolysis of ATP to AMP and PPi is -7.29 kcal/mol

G° for the ATP- dependent synthesis of acetyl-CoA = -7.29 + 7.69 = +0.4 kcal/mol

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