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C Chegg.com uno.mroomss.net/pluginf × Duno.mrooms3.net/pluginfile.php/1045202/mod.resource/content/2/CHEM3710H2-2015 pdf Problem 4 Nicotinic acetylcholine receptors are associated with sodium ion channel function and found throughout the body. The compound hexamethonium diiodide binds to nicotinic acetylcholine receptors but does not exhibit any central nervous system activity. However, nicotine exhibits potent CNS activity. Explain these results based up the structure of hexamethonium diiodide and nicotine. hexamethonium nicotine Problem 5 Levodopa is used as a treatment for Parkinson's Syndrome. Levodopa is metabolically converted into dopamine in order to increase dopamine levels in the brain. Direct administration of dopamine is not possible because dopamine is too polar to cross the blood brain barrier. Explain how the more polar levodopa might be able to enter the brain while dopamine is not. HO HO IK levodopa dopamine Problem 6 The uricosuric drugs (increase urination of uric acid/ anti-inflammatory) Butazolidine and Anturane are active in the anionic form. As the anions, these drugs block re-absorption of uric acid by renal eseenti 3:08 PM ^-1 4) 9/22/2015

Explanation / Answer

The potency and selectivity of the ligand influenced by the linker, substitution on the amino group and the pyridine ring.

Short chain ether linkers are preferred for binding.

In acetylcholine, amine group is linked with ether group with two carbon atoms whereas in hexamethonium diiodide, two amine groups are linked through six carbon atoms and no ether linkage. Hence no CNS acitivity found in the case fo hexamethonium diiodie.

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