Which of the following individuals would you predict to have a genetic predispos

Question

Which of the following individuals would you predict to have a genetic predisposition to food addiction?

A. Someone that is heterozygous for a nonsense mutation in the gene encoding dopamine

B. Someone that is heterozygous for a silent mutation in the gene encoding the dopamine re-uptake receptor protein

C. Someone that is heterozygous for a nonsense mutation in the gene encoding the dopamine re-uptake receptor protein

D. Someone that is heterozygous for a silent mutation in the gene encoding the dopamine receptor protein

E. Someone that is heterozygous for a nonsense mutation in the gene encoding the dopamine receptor protein

Explanation / Answer

Out of the following, the individual predicted to have a genetic predisposition to food addiction is :

E. Someone that is heterozygous for a nonsense mutation in the gene encoding the dopamine receptor protein

This is because according to research, the mutation in DRD2 which is the gene encoding for dopamine receptors, will increase the risk for developing addictive disorders, thus making an individual susceptible for food addiction. The type of mutation can be narrowed down to non-sense mutation since it creates a ore-mature stop codon. This will result in fewer receptors further increasing the addiction. On the other hand, the silent mutation will cause no difference to the receptor protein. Hence, the correct answer is option -E

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