[15] 2. In the article: Thompson LK. Unraveling the secrets of Alzheimer B-amylo

Question

[15] 2. In the article: Thompson LK. Unraveling the secrets of Alzheimer B-amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America 2003,100 (2) 383-385. doi: 10.1073/pnas.0337745100, the author describes the fibrils that form in the brains of certain misfolding disease patients. Taken from the article is the following image: Note marks for each point are given in square brackets 40 a. The number of individual proteins shown in this image is Iij b. What kind of B-sheets are shown in the image [1]: c. What is the length, in Angstroms, ofa darker strand [1] d. A stabilizing salt bridge is described in the article. On the closest peptide, draw aline between the residues described put the line in the approximate location and list the residue numbers [3] e. In the box on the top right comer of the image, for the two strands encompassed, draw how 4 amino acid residues in each would be oriented relative to each other, how they would interact with each other and for the sidechains, label simply as P (for polar) and N (for non-polar). Note, the article give information about the TYPE of residues these would be. [5] f. What main IMF would be found between the sheets in this image [1]

Explanation / Answer

1.

The Translation in a beta strand is 3.5 Angstroms/residue

24 residues x 3.5 angstroms=84 Armstrong

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