Why can\'t hydrophobic chemical messengers be synthesized ahead of time? How are
ID: 90710 • Letter: W
Question
Why can't hydrophobic chemical messengers be synthesized ahead of time? How are they released from the secretory cell? How are they transported in the blood? Where are their receptors found at the target cell? What is their general mechanism of action (signal transduction) at the target cell? You are a hematologist, and a patient of yours has a longer than normal blood clotting time. Tests show that the patient's clotting factors are all normal, but you discover that she produces a much lower than normal level of cyclooxygenase (an enzyme involved in the cyclooxygenase pathway) within her blood cells. Why might this affect her blood clotting process?Explanation / Answer
Hydrophobic (lipophilic) - example steroids.Molecules are lipid soluble and can easily cross the plasma membrane. if they synthesize ahead of time they will activate signalling without any regulation.
these are diffuse through cell membranes because of their lipophilic character. they cannot be stored in and are synthesized as needed and released immediately.
Hydrophobic messengers are transported in blood with binding to carrier proteins.
their receptor found on plasma membrane or in cytosol or in the nucleus (hydrophobic molecule easily cross the plasma membrane)
The messenger binds to the receptor and formed complex. then this complex activate or deactivate down stream molecule and finally activating or deactivating the process.
2) low level of COX protein------ reduced level of thromboxasane A2 synthesis--------- impaired/less platelet activation/ function-------- slow clotting process.
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