The presence of multiple hexokinase isozymes 0-M) for the phosphorylation of glu

Question

The presence of multiple hexokinase isozymes 0-M) for the phosphorylation of glucose enables specific organs to also calied arve in red) Note nce "e shapes of re arves wen 08 06 04 02 Please scroll down 026121 Determine whether the phrase describes Note: Assume that the kinetic behavior of sozymes in vivo is similar to in vitro (plot shown above). Note: If any part of this question is answered incorrectly, a single red X will appear indicating that one or more phrases have been placed incorrectly Hexokinase I, Il, orl All hexokinase isozymes (-M) will be saturated by plays an important role in liver reguiation Kn is in the range of physiologic blood when blood glucose levels glucose level's of blood glucose level lewels normal blood glucose concentrations all below normail r maintains maximum when blood glucose is low, not sensitive to inhibition by glucose 6-phosphate will cause cells to trap glucose

Explanation / Answer

Hexokinase I, II, III

will be saturated by normal blood glucose concentrations.

Subcellular localization is regulated by fructose-6-phosphate.

Glucokinase (Hexokinase IV)

Km is in the range of physiological glucose levels.

Will phosphorylate several hexoses including glucose.

Plays an important role in liver regulation of blood glucose level.

Not sensitive to inhibition by glucose-6-phosphate.

All Hexokinase enzyme I-IV

When blood glucose level falls below normal range, maintains maximum velocity.

When blood glucose level is low, will cause cells to trap glucose by phosphorylation.

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